Apr 30, 2019 Allegro Ophthalmics to Present the Results of Its ALG-1007 Ex-U.S. Trial for Dry Eye Disease at the 2019 ASCRS•ASOA Annual Meeting.

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“Allegro is excited to share our ex-U.S. proof-of-concept data of ALG-1007 for dry eye disease,” said Vicken Karageozian, M.D., President and CEO of Allegro Ophthalmics. “These early results suggest that ALG-1007 improves the signs and symptoms of dry eye, a disease that affects millions of people globally, with symptoms that include scratchy, stinging or burning sensations, and pain or 2019-05-17 · Results announced from ex-U.S. proof-of-concept trial with ALG-1007 for dry eye At its highest dose concentration (0.6%), the new investigational topical drug ALG-1007 (Allegro Ophthalmics) had statistically significant efficacy in nearly all assessments for dry eye and a more rapid onset of action compared to the lowest dose (0.125%), according to a company press release.

Alg-1007 allegro

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05.14.19. Allegro Announces Positive Results of Ex-US Proof-of-Concept Trial With ALG-1007 for Dry Eye Disease. Source: Allegro Ophthalmics. 04.30.19. Allegro to Present Results of Its ALG-1007 Ex-US Trial for Dry Eye Disease at ASCRS. Source: Allegro Ophthalmics.

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CHICAGO, IL — October 16, 2014 — Allegro Ophthalmics, LLC, dedicated to establishing integrin peptide therapy as the next-generation pharmaceutical category for the treatment of vitreoretinal diseases, today announced that it is enrolling patients in a Phase 2 trial that will evaluate the safety and efficacy of Luminate®, previously known as ALG-1001, in patients with diabetic macular edema (DME).

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2019-04-25 · Allegro Ophthalmics has added ALG-1007, a new anti-integrin drug candidate for the treatment of dry eye disease, to its portfolio, the company announced in a press release.The topical agent is

Alg-1007 allegro

proof-of-concept study in humans, and is currently being evaluated in a larger ex-U.S. Phase 2 study. For more information, visit www.allegroeye.com . “ALG-1007 represents Allegro’s first exploratory drug beyond the retina. We recognize the need to bring in independent external expertise that complements our company’s strengths and are thrilled to have such an outstanding group of advisors as Drs. Lindstrom, Holland and Donnenfeld help shape and accelerate our clinical program for dry eye disease.” Allegro has a clear path forward and is gearing up for a larger US Phase 2b/3 trial in dry AMD in 1H 2020 ALG-1007 for topical use in dry eye disease demonstrated an improvement in both signs and symptoms of DED Allegro has initiated a second larger exploratory ex-US DED study looking at higher doses in a vehicle-controlled study ALG-1007, a topical drop, is the company’s second exploratory integrin-regulating drug candidate. In May, Allegro announced that the ex-U.S.

ALG-1007 (Allegro Ophthalmics, San Juan Capistrano, CA, USA) is a topical application of risuteganib, a small peptide integrin regulator that modulates multiple integrin subunits, including integrin αM and β2, the subunits involved in complement 3 inflammatory pathways. ALG 1007, a peptide integrin inhibitor is being developed by Allegro Ophthalmics for the treatment of dry eye disease (DED). ALG 1007 inhibits the leucocyte ALG 1007 - AdisInsight ALG-1007 is a topical treatment in development for potential use in patients with dry eye disease (DED), a condition affecting millions of people in the United States. ALG-1007 bolsters Allegro’s existing anti-integrin portfolio, which includes risuteganib (Luminate ® ), currently being developed for diabetic macular edema (DME) and intermediate Expanding its integrin-regulating portfolio, Allegro has developed ALG-1007 for topical use in dry eye disease. ALG-1007 demonstrated promising results in an ex-U.S.
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ALG-1007 demonstrated a strong signal in an ex-U.S. proof-of-concept clinical trial in which it showed a dose response curve and that it was generally well-tolerated.

proof-of-concept study in humans, and is currently being evaluated in a larger ex-U.S.
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Allegro Ophthalmics announced the expansion of the company’s anti-integrin portfolio with the new topical dry eye disease drug candidate ALG-1007. ALG-1007 bolsters Allegro’s existing anti-integrin portfolio, which includes risuteganib (Luminate), currently being developed for diabetic macular edema (DME) and intermediate dry age-related

proof-of-concept clinical trial in which it showed a dose-response curve and that it was generally well-tolerated. Other ophthalmology assets of Allegro include ALG-1007, a topical integrin regulator under investigation for the treatment of dry eye disease.

Other ophthalmology assets of Allegro include ALG-1007, a topical integrin regulator under investigation for the treatment of dry eye disease. It is currently in Phase 2 development outside the United States. The Option payment totaling $50 million would be made in two tranches, with the first payment of $10 million upon signing.

proof-of-concept clinical trial concluded that ALG- 1007 was well-tolerated and demonstrated a dose-response with improvement of the signs and symptoms of DED as early as 2 weeks. “Allegro is excited to share our ex-U.S. proof-of-concept data of ALG-1007 for dry eye disease,” said Vicken Karageozian, M.D., President and CEO of Allegro Ophthalmics.

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